A review on Unmasking Merkel Cell Polyomavirus : From Discovery to Cancer Driver

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Open Access

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nThis is an unedited manuscript accepted for publication and provided as an Article in Press for early access at the author’s request. The article will undergo copyediting, typesetting, and galley proof review before final publication. Please be aware that errors may be identified during production that could affect the content. All legal disclaimers of the journal apply.n

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Year : 2025 [if 2224 equals=””]11/09/2025 at 2:23 PM[/if 2224] | [if 1553 equals=””] Volume : 02 [else] Volume : [/if 1553] | [if 424 equals=”Regular Issue”]Issue : [/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02 | Page :

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    Ms. Poonam,

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  1. Assistant Professor, Guru Kashi University, Department of Pharmacy, Talwandi Sabo, Dist. Bathinda, Punjab, 151302, India

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Abstract

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nMerkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%.This review integrates findings from six project chapters, spanning the viral molecular biology, host-virus interactions, clinical management, and public health strategies related to MCPyV and MCC. We detail key aspects of the viral genome, including the role of large T (LT) and small T (sT) antigens in promoting cell cycle dysregulation and inhibiting tumor suppressor pathways. Host immune surveillance, particularly T-cell and humoral responses, is explored in the context of viral persistence and immune evasion. Clinically, we discuss diagnostic approaches including serology and PCR, and highlight recent advances in immunotherapy and targeted treatments for MCC. Public health efforts, such as awareness campaigns and the potential for future vaccine development, are also evaluated.By synthesizing foundational discoveries with recent advances, this review underscores the complexity of MCPyV-associated oncogenesis and identifies critical gaps in knowledge. Future research should aim to clarify mechanisms of viral integration, identify early biomarkers of malignant progression, and develop preventive interventions tailored to at-risk populations.This review integrates findings from six project chapters, covering viral molecular biology, host virus interactions, clinical management, and public health strategies. We synthesize foundational discoveries with recent advances, identify knowledge gaps, and propose directions for future research to inform diagnostics, therapeutics, and preventive interventions.nn

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Keywords: Merkel cell polyomavirus (MCPyV), Merkel cell carcinoma (MCC), oncogenesis, viral integration, immunotherapy.

n[if 424 equals=”Regular Issue”][This article belongs to International Journal of Virus Studies ]

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How to cite this article:
nMs. Poonam. [if 2584 equals=”][226 wpautop=0 striphtml=1][else]A review on Unmasking Merkel Cell Polyomavirus : From Discovery to Cancer Driver[/if 2584]. International Journal of Virus Studies. 14/07/2025; 02(02):-.

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How to cite this URL:
nMs. Poonam. [if 2584 equals=”][226 striphtml=1][else]A review on Unmasking Merkel Cell Polyomavirus : From Discovery to Cancer Driver[/if 2584]. International Journal of Virus Studies. 14/07/2025; 02(02):-. Available from: https://journals.stmjournals.com/ijvs/article=14/07/2025/view=0

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  1. Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the 2009 H.P.M.H.G. Research Conference. J Natl Cancer Inst. 2010;102(10):692–4.
  2. Yuan J, et al. Prevalence of Merkel cell polyomavirus in healthy individuals. J Med Virol. 2016;88(5):837–42.
  3. Becker JC, et al. Merkel cell carcinoma: biology and treatment. Eur J Cancer. 2013;49(6):1248–57.
  4. Paulson KG, et al. Merkel cell carcinoma: current epidemiology, diagnosis, and management. J Am Acad Dermatol. 2014;71(3):569–80.
  5. Nghiem P, et al. Merkel cell carcinoma: a review of the literature. Am J Clin Oncol. 2007;30(2):211–6.
  6. Sadeghi N, et al. Merkel cell carcinoma: a review of the biology, diagnosis, and treatment. J Clin Oncol. 2015;33(34):3946–52.
  7. Vandeven NA, et al. Diagnosis and management of Merkel cell carcinoma. Am Fam Physician. 2016;94(11):893–900.
  8. Topalian SL, et al. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell. 2016;29(3):337–49.
  9. Ravi K, Mehta R. The role of vaccination in controlling the Merkel polymer virus in India. Vaccine. 2021;39(30):4147–52.
  10. Kessels R. Healthcare provider training in infectious disease management. Infect Dis Clin North Am. 2020;34(1):223–37.
  11. Nghiem P, et al. The role of immunotherapy in Merkel cell carcinoma. Nat Rev Clin Oncol. 2017;14(12):749–50.
  12. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096–100.
  13. Becker JC, Stang A. Merkel cell carcinoma. Nat Rev Dis Primers. 2013;1(1):1–2.
  14. Hussain A, et al. Merkel cell carcinoma: a review of the literature. Br J Dermatol. 2020;182(1):36–45.
  15. Bialasiewicz S, Whiley DM. Molecular and clinical aspects of Merkel cell polyomavirus. J Clin Virol. 2013;58(4):1–8.
  16. Ghosh P, Roy S. Emerging viral infections in India: The case of Merkel polymer virus. Indian J Med Res. 2021;153(2):112–20.
  17. Nanda S, Rao P. Epidemiological studies on the Merkel polymer virus in Indian populations. J Infect Dis Epidemiol. 2020;6(1):25–30.
  18. Chatterjee S, et al. Transmission dynamics of the Merkel polymer virus: Insights from recent outbreaks in India. Indian J Public Health. 2021;65(3):210–6.
  19. Verma R, Singh M. Role of public health measures in controlling the Merkel polymer virus spread in urban India. J Community Health. 2022;47(4):634–40.
  20. Desai P, et al. Clinical characteristics and treatment outcomes of Merkel polymer virus infections in India. J Clin Virol. 2021;137:104771.
  21. Sharma A, Gupta S. Public health response to the Merkel polymer virus: Lessons learned from India. Health Policy Plan. 2020;35(5):607–15.
  22. Kumar R, Sharma P. Community awareness and behavior towards the Merkel polymer virus in rural India. Indian J Community Med. 2022;47(1):45–50.
  23. Patel K. Impact of the Merkel polymer virus on healthcare systems in India. J Health Manag. 2021;23(2):141–50.
  24. Sahu D, Singh R. Viral infections in India: Focus on Merkel polymer virus epidemiology and control. J Vector Borne Dis. 2020;57(3):200–10.
  25. Bansal S. Community engagement in response to infectious disease outbreaks. Glob Health Action. 2020;13(1):1729005.
  26. Rosenberg ME. The role of behavioral science in responding to COVID-19. Behav Sci Policy. 2020;6(1):7–18.
  27. Lee S. Epidemiological characteristics of COVID-19. J Korean Med Sci. 2020;35(11):e102.
  28. Raina S. Understanding the transmission dynamics of viral infections. J Virus Erad. 2021;7(1):49–56.
  29. Stojanovic J, Ristic M. Impact of environmental factors on viral spread. Environ Sci Pollut Res. 2021;28(12):15000–12.

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International Journal of Virus Studies

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Volume 02
[if 424 equals=”Regular Issue”]Issue[/if 424][if 424 equals=”Special Issue”]Special Issue[/if 424] [if 424 equals=”Conference”][/if 424] 02
Received 30/06/2025
Accepted 10/07/2025
Published 14/07/2025
Retracted
Publication Time 14 Days

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