A study on the impact of Paracetamol on Male Reproductive System: A Mini Review

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Year : 2025 | Volume : 15 | 02 | Page : –
    By

    Pragati C. Pandhare,

  • Varsha T. Dhurvey,

  • Harshada B. Pawar,

  1. Student, Department of Zoology, RTM Nagpur University, Nagpur, Maharashtra, India
  2. Professor, Department of Zoology, RTM Nagpur University, Nagpur, Maharashtra, India
  3. Student, Department of Zoology, RTM Nagpur University, Nagpur, Maharashtra, India

Abstract

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Paracetamol, a widely used analgesic and antipyretic, has been studied for its potential effects on the male reproductive system. Paracetamol is a medication commonly used to relieve mild to moderate pain. Research suggests that prolonged or high-dose use of paracetamol may adversely affect male fertility by disrupting hormone regulation, impairing sperm production, and reducing testosterone levels. Studies have shown that paracetamol can interfere with the hypothalamic- pituitary-gonadal axis, leading to changes in testicular function, sperm count, motility, and morphology. Additionally, oxidative stress and alterations in enzymatic activity in the testes have been observed. While the exact mechanisms remain unclear, it is recommended that caution be exercised regarding prolonged or excessive use of paracetamol, especially in individuals concerned about fertility. To completely comprehend its long-term implications on male reproductive health, more research is required.

Keywords: Paracetamol, testes, sperm abnormalities, hormones, Acetaminophen.

How to cite this article:
Pragati C. Pandhare, Varsha T. Dhurvey, Harshada B. Pawar. A study on the impact of Paracetamol on Male Reproductive System: A Mini Review. Research and Reviews: A Journal of Pharmacology. 2025; 15(02):-.
How to cite this URL:
Pragati C. Pandhare, Varsha T. Dhurvey, Harshada B. Pawar. A study on the impact of Paracetamol on Male Reproductive System: A Mini Review. Research and Reviews: A Journal of Pharmacology. 2025; 15(02):-. Available from: https://journals.stmjournals.com/rrjop/article=2025/view=0


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Ahead of Print Subscription Review Article
Volume 15
02
Received 05/04/2025
Accepted 22/04/2025
Published 14/05/2025
Publication Time 39 Days
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