Omega-3 Fatty Acids and Brainpower: The Role of Seafood Consumption


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Year : 2025 | Volume : | | Page : –
    By

    Ajit Pal Singh,

  • Rahul Saxena,

  • Suyash Saxena,

  1. Assistant Professor, Department of Medical Lab Technology, SSAHS, Sharda University, Gr. Noida, U.P, India
  2. Professor, Department of Biochemistry, SSAHS, Sharda University, Gr. Noida, India
  3. Assistant Professor, Department of Biochemistry, SSAHS, Sharda University, Gr. Noida, India

Abstract

The following article talks about the strong link between eating seafood and brain health, focusing on the role of omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in supporting brain development, function, and longevity. The article uses new research to show how these important polyunsaturated fatty acids help the brain in ways like memory, learning, focus, and attention. It also reduces the chance of developing dementia, Alzheimer’s, and other neurological diseases. Better mood control and better sleep, both crucial for overall brain health, are also associated with omega-3s. Some of the best places to get EPA and DHA are from fatty fish, like mackerel, tuna, salmon, and sardines. Concerns about environmental pollutants, particularly mercury, are also prevalent. The article provides evidence-based guidance on selecting low-mercury fish, such as wild Alaskan salmon and sardines. Because environmental worries are growing, it stresses how important it is to choose sustainable seafood and supports responsible sourcing to protect marine ecosystems and human health for future generations. The piece stresses the importance of sustainable seafood in protecting our oceans and our health by encouraging people to eat in a way that is beneficial for the environment.

Keywords: Effects, Health, Research, Memory, Fatty acids.

How to cite this article:
Ajit Pal Singh, Rahul Saxena, Suyash Saxena. Omega-3 Fatty Acids and Brainpower: The Role of Seafood Consumption. International Journal of Brain Sciences. 2025; ():-.
How to cite this URL:
Ajit Pal Singh, Rahul Saxena, Suyash Saxena. Omega-3 Fatty Acids and Brainpower: The Role of Seafood Consumption. International Journal of Brain Sciences. 2025; ():-. Available from: https://journals.stmjournals.com/ijbs/article=2025/view=197148


References

  1. Darmawan A, Wulandari N, Nurjanah S, Sugiarto AT, Kusumaningrum HD. Optimization of pulsed electric field design for seafood products with salting process. In: IOP Conference Series: Earth and Environmental Science. 2024 Jun;1359(1):012020. IOP Publishing.
  2. Russo GL, Langellotti AL, Torrieri E, Masi P. Emerging technologies in seafood processing: An overview of innovations reshaping the aquatic food industry. Compr Rev Food Sci Food Saf. 2024;23(1):e13281.
  3. Holm P, Hayes P, Nicholls J. Historical marine footprint for Atlantic Europe, 1500–2019. Ambio. 2024;53(4):624-36.
  4. Zhang J, Ahmmed MK, Regenstein JM, Wu H. Recent advances of recycling proteins from seafood by-products: Industrial applications, challenges, and breakthroughs. Trends Food Sci Technol. 2024;104533.
  5. Gurel M, Rathod N, Cabrera LY, Voyton S, Yeo M, Ozogul F, Ozbolat IT. A narrative review: 3D bioprinting of cultured muscle meat and seafood products and its potential for the food industry. Trends Food Sci Technol. 2024;104670.
  6. Saaoud F, Lu Y, Xu K, Shao Y, Praticò D, Vazquez-Padron RI, et al. Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers–Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer. Pharmacol Ther. 2024;108604.
  7. Liu WJ, Liu P, Lei W, Jia Z, He X, Shi W, et al. Surveillance of SARS-CoV-2 at the Huanan seafood market. Nature. 2024;631(8020):402-8.
  8. Chandrababu A, Puthumana J. CRISPR-edited, cell-based future-proof meat and seafood to enhance global food security and nutrition. Cytotechnology. 2024;1-34.
  9. Brauge T, Mougin J, Ells T, Midelet G. Sources and contamination routes of seafood with human pathogenic Vibrio spp.: A Farm‐to‐Fork approach. Compr Rev Food Sci Food Saf. 2024;23(1):e13283.
  10. Tacon AG, Coelho RT, Levy J, Machado TM, Neiva CR, Lemos D. Annotated bibliography of selected papers dealing with the health benefits and risks of fish and seafood consumption. Rev Fish Sci Aquacult. 2024;32(2):211-305.
  11. Lorusso L, Shum P, Piredda R, Mottola A, Maiello G, Cartledge EL, et al. Mismanagement and poor transparency in the European processed seafood supply revealed by DNA metabarcoding. Food Res Int. 2024;114901.
  12. Varzakas T, Smaoui S. Global food security and sustainability issues: the road to 2030 from nutrition and sustainable healthy diets to food systems change. Foods. 2024;13(2):306.
  13. Akhila DS, Ashwath PG, Manjunatha KG, Akshay SD, Surasani VKR, Sofi FR, et al. Seafood processing waste as a source of functional components: Extraction and applications for various food and non-food systems. Trends Food Sci Technol. 2024;104348.
  14. Bjørndal T, Dey M, Tusvik A. Economic analysis of the contributions of aquaculture to future food security. Aquaculture. 2024;578:740071.
  15. Singh AP, Saxena R, Saxena S, Maurya NK. Unveiling the Ocean’s Arsenal: Successful Integration of Marine Metabolites into Disease Management. Uttar Pradesh J Zool. 2024;45(13):170-88.
  16. Morales-Nin B, Zimmermann F, Merino G, Antelo LT, Murillas-Maza A, Moksness E. Challenges on blue food provision. Front Ocean Sustain. 2024;2:1271783.
  17. Steinhagen S, Stedt K, Trigo JP, Undeland I, Pavia H. A step towards closing the food-waste gap in novel protein sources: Post-harvest protein boost of the seaweed crop Ulva by herring production tub water. Future Foods. 2024;9:100347.
  18. Han K, Yeom J, Chung K. Identifying Emerging Issues in the Seafood Industry Based on a Text Mining Approach. Appl Sci. 2024;14(5):1820.
  19. Karimidastjerd A, Gulsunoglu-Konuskan Z, Ersoy B, Cetinkaya T, Khan ZS, Okpala COR. Nutritional and sustainability aspects of algae and fungi sources in the seafood analogs. Ann Anim Sci. 2024.
  20. Lee YC, Kim HG, Jeong JC, Kang CS. Current Trends and Prospects of High Value-added Seafood Processing Technology Development. J Pract Agric Fish Res. 2024;25(4):148-57.
  21. Singh AP, Saxena R, Saxena S, Maurya NK. Artificial Intelligence Revolution in Healthcare: Transforming Diagnosis, Treatment, and Patient Care. Asian J Adv Res. 2024;7(1):241-63.
  22. Tacon AG, Shumway SE. Critical need to increase aquatic food production and food supply from aquaculture and capture fisheries: trends and outlook. Rev Fish Sci Aquacult. 2024;32(3):389-95.
  23. Desai AK, Desai AK, Rush J, Naveen L, Thaipisuttikul P. Nutrition and nutritional supplements to promote brain health. In: Enhancing Cognitive Fitness in Adults: A Guide to the Use and Development of Community-Based Programs. 2011. p. 249-69.
  24. Park J. The role of diet and nutrition in brain health and concentration. Brain. 2023.
  25. Ahire ED, Keservani RK, Bharti SK. Role of fruit and food components in brain cognition. In: Nutraceutical Fruits and Foods for Neurodegenerative Disorders. Academic Press; 2024. p. 1-14.
  26. Power R, Prado-Cabrero A, Mulcahy R, Howard A, Nolan JM. The role of nutrition for the aging population: implications for cognition and Alzheimer’s disease. Annu Rev Food Sci Technol. 2019;10:619-39.
  27. Hale J. The Truth About Nootropic Brain Supplements and Brain Power. 2023.
  28. Tardner P. Memory Supplements: Best supplements for brain health and memory. 2020.
  29. Smarta R. Nutrition needs for lifestyle changes and managing disorders. In: Nutrition Science, Marketing Nutrition, Health Claims, and Public Policy. Academic Press; 2023. p. 45-56.
  30. Donahue SM, Rifas-Shiman SL, Gold DR, Jouni ZE, Gillman MW, Oken E. Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort. Am J Clin Nutr. 2011;93(4):780-8.
  31. Nurk E, Drevon CA, Refsum H, Solvoll K, Vollset SE, Nygård O, Nygaard HA, Engedal K, Tell GS, Smith AD. Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr. 2007 Nov 1;86(5):1470-8.
  32. Morris MC, Brockman J, Schneider JA, Wang Y, Bennett DA, Tangney CC, van de Rest O. Association of seafood consumption, brain mercury level, and APOE ε4 status with brain neuropathology in older adults. Jama. 2016 Feb 2;315(5):489-97.
  33. Singh AP, Saxena R, Saxena S, Maurya NK. Mind Unveiled: Cutting-Edge Neuroscience and Precision Brain Mapping. Asian J Curr Res. 2024;9(3):181-95.
  34. Kim DH, Grodstein F, Rosner B, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Seafood types and age-related cognitive decline in the Women’s Health Study. J Gerontol A Biol Sci Med Sci. 2013 Oct 1;68(10):1255-62.
  35. Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Fish consumption and cognitive decline with age in a large community study. Arch Neurol. 2005 Dec 1;62(12):1849-55.
  36. van de Rest O, Wang Y, Barnes LL, Tangney C, Bennett DA, Morris MC. APOE ε4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. 2014.
  37. Yoshimura H. Neuroplasticity and Nutrition: The Role of Diet in Brain Resilience and Repair. Nutr. 2016 May 31;86(22):2063-70.
  38. Singh AP, Saxena R, Saxena S, Maurya NK. The Future of Protection: Unleashing the Power of Nanotech against Corrosion. Asian J Curr Res. 2024;9(3):23-44.
  39. Mao X, Chen C, Xun P, Daviglus M, Steffen LM, Jacobs Jr DR, Van Horn L, Sidney S, Zhu N, He K. Effects of seafood consumption and toenail mercury and selenium levels on cognitive function among American adults: 25 y of follow up. Nutr. 2019 May 1;61:77-83.
  40. Nooyens AC, Van Gelder BM, Bueno-de-Mesquita HB, Van Boxtel MP, Verschuren WM. Fish consumption, intake of fats and cognitive decline at middle and older age: the Doetinchem Cohort Study. Eur J Nutr. 2018 Jun;57:1667-75.
  41. Avella-Garcia CB, Julvez J. Seafood intake and neurodevelopment: a systematic review. Curr Environ Health Rep. 2014 Mar;1:46-77.
  42. Cardoso C, Afonso C, Bandarra NM. Dietary DHA and health: cognitive function ageing. Nutr Res Rev. 2016 Dec;29(2):281-94.
  43. Hei A. Mental health benefits of fish consumption. Clin Schizophr Relat Psychoses. 2020;15(5).
  44. Bushkin-Bedient S, Carpenter DO. Benefits versus risks associated with consumption of fish and other seafood. Rev Environ Health. 2010 Sep;25(3):161-92.
  45. Cohen JF, Gorski MT, Gruber SA, Kurdziel LB, Rimm EB. The effect of healthy dietary consumption on executive cognitive functioning in children and adolescents: a systematic review. Br J Nutr. 2016 Sep;116(6):989-1000.
  46. Kalmijn SV, Van Boxtel MP, Ocke M, Verschuren WM, Kromhout D, Launer LJ. Dietary intake of fatty acids and fish in relation to cognitive performance at middle age. Neurology. 2004 Jan 27;62(2):275-80.
  47. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. Jama. 2006 Oct 18;296(15):1885-99.
  48. Assisi A, Banzi R, Buonocore C, Capasso F, Di Muzio V, Michelacci F, Renzo D, Tafuri G, Trotta F, Vitocolonna M, Garattini S. Fish oil and mental health: the role of n-3 long-chain polyunsaturated fatty acids in cognitive development and neurological disorders. Int Clin Psychopharmacol. 2006 Nov 1;21(6):319-36.
  49. Liu C, Ralston NV. Seafood and health: What you need to know?. In: Adv Food Nutr Res. 2021 Jan 1;97:275-318.
  50. Oken E, Wright RO, Kleinman KP, Bellinger D, Amarasiriwardena CJ, Hu H, Rich-Edwards JW, Gillman MW. Maternal fish consumption, hair mercury, and infant cognition in a US cohort. Environ Health Perspect. 2005 Oct;113(10):1376-80.
  51. Sasaki N, Jones LE, Carpenter DO. Fish consumption and omega-3 polyunsaturated fatty acids from diet are positively associated with cognitive function in older adults even in the presence of exposure to lead, cadmium, selenium, and methylmercury: a cross-sectional study using NHANES 2011–2014 data. Am J Clin Nutr. 2024 Feb 1;119(2):283-93.
  52. Qin B, Plassman BL, Edwards LJ, Popkin BM, Adair LS, Mendez MA. Fish intake is associated with slower cognitive decline in Chinese older adults. J Nutr. 2014 Oct 1;144(10):1579-85.
  53. Shaffer J. Neuroplasticity and clinical practice: Building brain power for health. Front Psychol. 2016;7:205377.
  54. Dougherty P. How Much Omega 3 Per Day for Bodybuilding-Here’s How Much You Need!. Omega. 3. 0.
  55. Kuempel CD, Arnett E, Klein CJ. Quantifying global redundant fisheries trade to streamline seafood supply chains. PLoS One. 2024;19(7):e0305779.
  56. Mahmud N, Valizadeh S, Oyom W, Tahergorabi R. Exploring functional plant-based seafood: Ingredients and health implications. Trends Food Sci Technol. 2024;104346.
  57. Lester SE, Gentry RR, Froehlich HE. The role of marine aquaculture in contributing to the diversity and stability of US seafood production. Mar Policy. 2024;160:105994.
  58. McClements DJ. Novel animal product substitutes: A new category of plant‐based alternatives to meat, seafood, egg, and dairy products. Compr Rev Food Sci Food Saf. 2024;23(3):e313330.
  59. Shum P, Cusa M, Prasetyo A, Mariani S. Nanopore sequencing facilitates screening of diversity and provenance of seafood and marine wildlife. Food Control. 2024;161:106908.
  60. Lee JH. Proteomic investigation of key proteins involved in the manufacture of plant-based seafood. Food Res Int. 2024;141:109827.
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Received 13/01/2025
Accepted 01/02/2025
Published 05/02/2025
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