Varsha Ratan Gaikwad,
Anjali Singh,
Hritika Sawant,
Urvashi Pethe,
Sanjivani Rajput,
Ambika Nand Jha,
- Assistant Professor, Dept. of Pharmacognosy, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
- Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
- Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra,
- Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
- Students, B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi, Maharashtra, India
- Assistant Professor, Department of Pharmacy Practice, School of Pharmacy, Maharashtra, India
Abstract
The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic properties. Extensive preclinical studies have demonstrated that wogonin exerts anti-tumor effects by inducing cell cycle arrest, promoting apoptosis, and inhibiting metastasis. This review provides a comprehensive analysis of published studies highlighting wogonin’s chemo-preventive potential and the underlying molecular mechanisms of its anti-cancer activity. It also explores the synergistic effects of wogonin in enhancing the efficacy of conventional chemotherapy. Further research into the chemistry and toxicological profile of wogonin is encouraged to ensure its safety and optimize its therapeutic application, positioning it as a promising candidate for cancer treatment. Scutellaria baicalensis Georgi, a species of the Labiaceae family, is a medicinal herb widely used in traditional Chinese medicine (TCM). It contains many ingredients, the main active ingredients in Scutellaria baicalensis Georgi are flavonoids such as baicalin, baicalein, and wogonin, Apart from above properties, Scutellaria alone, or in combination with other herbs, has been recently shown to possess cytostatic effect on several cancer cell lines in vitro and also in vivo in mouse tumor models.
Keywords: Wogonin, herbal drug, anticancer, targeted therapies, Scutellaria baicalensis Georgi.
Varsha Ratan Gaikwad, Anjali Singh, Hritika Sawant, Urvashi Pethe, Sanjivani Rajput, Ambika Nand Jha. The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases. Research & Reviews: A Journal of Pharmacognosy. 2024; ():-.
Varsha Ratan Gaikwad, Anjali Singh, Hritika Sawant, Urvashi Pethe, Sanjivani Rajput, Ambika Nand Jha. The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases. Research & Reviews: A Journal of Pharmacognosy. 2024; ():-. Available from: https://journals.stmjournals.com/rrjopc/article=2024/view=180501
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Research & Reviews: A Journal of Pharmacognosy
Volume | |
Received | 04/10/2024 |
Accepted | 21/10/2024 |
Published | 29/10/2024 |