The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases

Year : 2024 | Volume : | : | Page : –
By

Varsha Ratan Gaikwad,

Anjali Singh,

Hritika Sawant,

Urvashi Pethe,

Sanjivani Rajput,

Ambika Nand Jha,

  1. Assistant Professor, Dept. of Pharmacognosy, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
  2. Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
  3. Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra,
  4. Student B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Maharashtra, India
  5. Students, B.Pharm, Shri Pandit Baburao Chaughule College of Pharmacy, Bhiwandi, Maharashtra, India
  6. Assistant Professor, Department of Pharmacy Practice, School of Pharmacy, Maharashtra, India

Abstract

The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic properties. Extensive preclinical studies have demonstrated that wogonin exerts anti-tumor effects by inducing cell cycle arrest, promoting apoptosis, and inhibiting metastasis. This review provides a comprehensive analysis of published studies highlighting wogonin’s chemo-preventive potential and the underlying molecular mechanisms of its anti-cancer activity. It also explores the synergistic effects of wogonin in enhancing the efficacy of conventional chemotherapy. Further research into the chemistry and toxicological profile of wogonin is encouraged to ensure its safety and optimize its therapeutic application, positioning it as a promising candidate for cancer treatment. Scutellaria baicalensis Georgi, a species of the Labiaceae family, is a medicinal herb widely used in traditional Chinese medicine (TCM). It contains many ingredients, the main active ingredients in Scutellaria baicalensis Georgi are flavonoids such as baicalin, baicalein, and wogonin, Apart from above properties, Scutellaria alone, or in combination with other herbs, has been recently shown to possess cytostatic effect on several cancer cell lines in vitro and also in vivo in mouse tumor models.

Keywords: Wogonin, herbal drug, anticancer, targeted therapies, Scutellaria baicalensis Georgi.

How to cite this article:
Varsha Ratan Gaikwad, Anjali Singh, Hritika Sawant, Urvashi Pethe, Sanjivani Rajput, Ambika Nand Jha. The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases. Research & Reviews: A Journal of Pharmacognosy. 2024; ():-.
How to cite this URL:
Varsha Ratan Gaikwad, Anjali Singh, Hritika Sawant, Urvashi Pethe, Sanjivani Rajput, Ambika Nand Jha. The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases. Research & Reviews: A Journal of Pharmacognosy. 2024; ():-. Available from: https://journals.stmjournals.com/rrjopc/article=2024/view=180501

References

[1] Park HG, Yoon SY, Choi JY, Lee GS, Choi JH, Shin CY, et al. Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. Eur J Pharmacol 2007;574(2–3):112–9
[2] Cao Z. Wogonin: A Review of Its Pharmacological and Pharmacokinetic Properties. Phytotherapy Research*. 2020;34(3):617–29
[3] Liu W. Wogonin inhibits tumor growth by targeting multiple signaling pathways. Cancer Letters. 2016;380(2):297–306.
[4] Liu W. Wogonin inhibits tumor growth by targeting multiple signaling pathways. Cancer Letters. 2016;380(2):297–306.
[5] Cao Z. Wogonin: A Review of Its Pharmacological and Pharmacokinetic Properties. Phytotherapy Research*. 2020;34(3):617–29
[6] Rouhani M, Dalfard A. Wogonin from Scutellaria baicalensis-Induced Radioresistance in MCF-7 Breast Cancer Cell Line. EJMO. 2022;6(4):345–50.
[7] Tronina T, Mrozowska M, Bartmańska A, Popłoński J, Sordon S, Huszcza E. Simple and rapid method for wogonin preparation and its biotransformation. Int J Mol Sci 2021;22(16):8973 http://dx.doi.org/10.3390/ijms22168973
[8] Herbal Drug Regulations in India and the Case of Wogonin
[9] Wang Q, Shi R, Dai Y, Li Y, Wang T, Ma Y, et al. Mechanism in the existent difference in form of wogonin/wogonoside between plasma and intestine/liver in rats. RSC Adv . 2018;8(7):3364–73. http://dx.doi.org/10.1039/c7ra08270
[10] Zhao J. Scutellaria baicalensis Georgi: A review of its pharmacological properties and clinical applications. Frontiers in Pharmacology. 2017
[11] Lee JH. Optimization of extraction conditions for flavonoids from Scutellaria baicalensis. Journal of Medicinal Food. 2015
[12] Wang J. Preparation and evaluation of the extracts of Scutellaria baicalensis by different grinding techniques. Journal of Traditional Chinese Medicine. 2018;
[13] Lin L. Selection of solvents for flavonoid extraction from medicinal plants. Journal of Chromatography. 2014
[14] Zhang X. Comparison of different extraction methods for wogonin from Scutellaria baicalensis. Phytochemical Analysis. 2016
[15] Hu X. Filtration techniques for the extraction of bioactive compounds. Industrial Crops and Products. 2020;
[16] Liu X. Extraction and Processing Technology for Biobased Products. 2019.
[17] Chen J. Purification of flavonoids from medicinal plants using chromatography. Journal of Separation Science. 2017
[18] Zheng Y. Spectroscopic methods for the analysis of flavonoids. Analytical Chemistry. 2018
[19] Zhang W. Identification of wogonin and its analogs using NMR and MS. Journal of Natural Products. 2019
[20] Xu Y. Quantitative analysis of wogonin using HPLC. Journal of Pharmaceutical and Biomedical Analysis. 2021
[21] Shi J. Storage stability of bioactive compounds. Food Chemistry. 2018
[22] Li, HB, Jiang, Y, and Chen, F. Separation methods used for Scutellaria baicalensis active components. J Chromatogr B Analyt Technol Biomed Life Sci. (2004)
[23] Rawat S, Gupta G, Pathak S, Singh SK, Singh H, Mishra A, et al. Current biological and pharmacological updates on wogonin . IfADo – Leibniz Research Centre for Working Environment and Human Factors, Dortmund; 2020.

 


Ahead of Print Subscription Review Article
Volume
Received 04/10/2024
Accepted 21/10/2024
Published 29/10/2024