To Investigate Hormonal Fluctuations in Male Rattus norvegicus after Treatment with 50% Methanolic Extract of Acacia Arabica

Year : 2024 | Volume : | : | Page : –
By

Alka Qureshi,

Sonalika Singh,

Madhvi Senwelka,

  1. Scholar, Department of Zoology, Institute of Allied Medical Sciences and Technology. Nims University, Jaipur, Rajasthan, India
  2. Associate Professor, Department of Zoology, Institute of Allied Medical Sciences and Technology. Nims University, Jaipur, Rajasthan, India
  3. Assistant Professor, Department of Pathology, National Institute of Medical sciences. Nims University , Jaipur, Rajasthan, India

Abstract

The use of medicinal plants in traditional and modern medicine has garnered significant interest for their therapeutic potential. Acacia arabica, commonly known as babul, is renowned for its bioactive compounds and diverse pharmacological properties. This study investigates the hormonal fluctuations induced by 50% methanolic extract of Acacia arabica in male Rattus norvegicus, aiming to explore its potential as a male contraceptive.
Male contraception remains limited primarily to condoms and vasectomy, necessitating the development of new, effective, and reversible methods. Because of their organic nature and reputed safety, organic contraception provides a possible option. Acacia arabica has shown antifertility effects in previous studies, suggesting it may interfere with spermatogenesis or hormonal regulation.
the present research, sixty consecutive days of oral administration of Acacia arabica extract at dosages of 100, 200, and 300 mg/kg were given to male albino Wistar rats. To determine how it affected male reproductive health, the levels of the hormones testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured. Results indicated a dose-dependent reduction in sperm motility and density, with significant declines observed at higher doses. Fertility tests revealed decreased reproductive success, highlighting compromised sperm function and viability.
Histopathological analysis of testicular tissues further supported these findings, showing dose-dependent degeneration of seminiferous tubules and reduction in spermatogenic cells. Similar degenerative changes were observed in the epididymis, seminal vesicles, and prostate gland, suggesting broad systemic effects of the extract on male reproductive organs.
These findings underscore the potential of Acacia arabica as a modulator of male reproductive hormones and fertility. Further research is warranted to elucidate its mechanisms of action and assess long-term effects, aiming towards the development of novel, plant-based contraceptives that are both effective and safe.

Keywords: Acacia arabica, male contraception, spermatogenesis, hormonal fluctuations, Rattus norvegicus.

How to cite this article:
Alka Qureshi, Sonalika Singh, Madhvi Senwelka. To Investigate Hormonal Fluctuations in Male Rattus norvegicus after Treatment with 50% Methanolic Extract of Acacia Arabica. Research & Reviews : Journal of Herbal Science. 2024; ():-.
How to cite this URL:
Alka Qureshi, Sonalika Singh, Madhvi Senwelka. To Investigate Hormonal Fluctuations in Male Rattus norvegicus after Treatment with 50% Methanolic Extract of Acacia Arabica. Research & Reviews : Journal of Herbal Science. 2024; ():-. Available from: https://journals.stmjournals.com/rrjohs/article=2024/view=172357



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Ahead of Print Subscription Original Research
Volume
Received August 28, 2024
Accepted September 10, 2024
Published September 17, 2024
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