Chenna M Shalini,
Asireddy Sathvika Reddy,
Vallarapu Nanda Krishna Veni,
Madhira Jayaprakash,
Rama Rao T,
- Associate Professor, Department of Pharmaceutics, CMR College of Pharmacy, Hyderabad, Telangana, India
- Research Scholar, Department of Pharmacy, CMR College of Pharmacy, Hyderabad, Telangana, India
- Research Scholar, Department of Pharmacy, CMR College of Pharmacy, Hyderabad, Telangana, India
- Research Scholar, Department of Pharmacy, CMR College of Pharmacy, Hyderabad, Telangana, India
- Principal, CMR College of Pharmacy, Hyderabad, Telangana, India
Abstract
This study had the goal to formulate oral polymeric thin film that would dissolve and disintegrate instantly, while also having high mechanical features. These are the most advanced forms of solid dosage forms. Solvent casting was the technique employed to create oral thin films. These are additionally referred to as buccal films/strip, mouth dissolving films, oral thin films, as well as oral strips of paper. These films are suitable for both elderly and young individuals because they dissolve instantly and do not require water. Their quick dissolution facilitates rapid drug absorption through the oral mucosa, enhancing bioavailability and enabling swift onset of action, which is particularly vital for medications requiring immediate effects or emergency situations. Advantages of these films include convenient dosing, no risk of chocking, patient compliance, site specific and local action. Special features of these films include dose accuracy, mucoadhesive, rapid release. For the manufacturing of oral thin film, ondansetron hydrochloride, an antiemetic drug categorized into BCS class II, was employed. Ondansetron is used for the prevention of the symptoms of chemotherapy-induced nausea and vomiting. It is an antagonist belonging to the serotonin 5-HT3 receptor class. To optimize the polymers HPMC E15, polymer content, plasticizer (glycerol, propylene glycol), and sweetener (aspartame), the formulations from the preliminary trial were investigated. The thickness, folding durability, drug content, swelling index, surface pH, in vitro disintegration time, along with in vitro dissolution investigations of the resulting films were investigated. Propylene glycol-prepared oral thin films responded better than the ones developed with glycerol plasticizer with regard to solubility and the breakdown capabilities. In less than 30 seconds, the optimal film (F2) began to break down, releasing more (92.23). By subjecting the data to statistical analysis (ANOVA) the observed f value is 1.36 and p value is 0.252.
Keywords: Oral thin films, ondansetron, polymers, solvent casting method, drug delivery systems.
Chenna M Shalini, Asireddy Sathvika Reddy, Vallarapu Nanda Krishna Veni, Madhira Jayaprakash, Rama Rao T. Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation. Research & Reviews: A Journal of Drug Design & Discovery. 2024; ():-.
Chenna M Shalini, Asireddy Sathvika Reddy, Vallarapu Nanda Krishna Veni, Madhira Jayaprakash, Rama Rao T. Oral Thin Films of Ondanetron Hcl: Formulation and Performance Evaluation. Research & Reviews: A Journal of Drug Design & Discovery. 2024; ():-. Available from: https://journals.stmjournals.com/rrjoddd/article=2024/view=171649
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| Volume | |
| Received | July 30, 2024 |
| Accepted | August 28, 2024 |
| Published | September 10, 2024 |