Mohammad Nadeem Khan
Ashok Kumar
Praveen Chand Dubey
Mohammad Rafi
Abstract
As of right now, there is no precise definition for nutraceuticals that distinguishes them from other food-based categories such herbal products, dietary supplements, pre- and probiotics, functional foods, and fortified foods. Several studies have shed light on the possible mechanisms of action of pharmaceutically active ingredients in food, emphasizing their ability to improve health, lower the risk of disease, and promote general wellbeing. However, Nutraceuticals confront difficulties in substantiating safety and health claims because national laws differ. It could be wise for national competent authorities to ask manufacturers to provide information on the safety, effectiveness, and mode of action for any claims made on product labels in order to address these issues, especially if the term “nutraceutical” is used. It might be possible to enhance the current regulatory environment by implementing such suggestions. Future developments in the creation of nutraceutical products may enhance toxicity, efficacy, and safety while offering a secure means of treating dangerous conditions. Despite the gaps in the current understanding of nutraceuticals, people need to change their mindset, prioritize concerns about drug interactions, side effects, and adverse reactions, and strive toward establishing a new paradigm of “Health for All” through creative dietary and lifestyle choices.
Keywords: Lifestyles, life-threatening diseases, awareness, nutraceuticals, traditional medicine, pharmacovigilance, safety
[This article belongs to Recent Trends in Infectious Diseases(rtid)]
References
Chang HF, Yang LL. Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. Molecules. 2012 Jul 3;17(7):8010-21.
Prinz-Langenohl R, Fohr I, Pietrzik K. Beneficial role for folate in the prevention of colorectal and breast cancer. European journal of nutrition. 2001 Jun;40:98-105.
Modem S, DiCarlo SE, Reddy TR. Fresh garlic extract induces growth arrest and morphological differentiation of MCF7 breast cancer cells. Genes & cancer. 2012 Feb;3(2):177-86.
Talib WH. Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation. Nutrition. 2017 Nov 1;43:89-97.
Vijayakumar S, Malaikozhundan B, Saravanakumar K, Durán-Lara EF, Wang MH, Vaseeharan B. Garlic clove extract assisted silver nanoparticle–Antibacterial, antibiofilm, antihelminthic, anti-inflammatory, anticancer and ecotoxicity assessment. Journal of Photochemistry and Photobiology B: Biology. 2019 Sep 1;198:111558.
Kronski E, Fiori ME, Barbieri O, Astigiano S, Mirisola V, Killian PH, Bruno A, Pagani A, Rovera F, Pfeffer U, Sommerhoff CP. miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and-2. Molecular oncology. 2014 May 1;8(3):581-95.
Simboli-Campbell M, Narvaez CJ, VanWeelden K, Tenniswood M, Welsh J. Comparative effects of 1, 25 (OH) 2 D 3 and EB1089 on cell cycle kinetics and apoptosis in MCF-7 breast cancer cells. Breast cancer research and treatment. 1997 Jan;42:31-41.
Wang Q, Lee D, Sysounthone V, Chandraratna RA, Christakos S, Korah R, Wieder R. 1, 25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function-and cell-specific additive effects. Breast cancer research and treatment. 2001 May;67:
157-68.
Zhu X, Xiong L, Zhang X, Shi N, Zhang Y, Ke J, Sun Z, Chen T. Lyophilized strawberries prevent 7, 12-dimethylbenz [α] anthracene (DMBA)-induced oral squamous cell carcinogenesis in hamsters. Journal of functional foods. 2015 May 1;15:476-86.
Petiwala SM, Johnson JJ. Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity. Cancer letters. 2015 Oct 28;367(2):93-102.
Vinothkumar V, Manoharan S, Sindhu G, Nirmal MR, Vetrichelvi V. Geraniol modulates cell proliferation, apoptosis, inflammation, and angiogenesis during 7, 12-dimethylbenz [a] anthracene-induced hamster buccal pouch carcinogenesis. Molecular and cellular biochemistry. 2012 Oct;369:17-25.
Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB. Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochemical pharmacology. 2010 Dec 15;80(12):1833-43.
Al-Okbi SY. Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis. Toxicology and industrial health. 2014 Sep;30(8):738-49.
Vecchione R, Quagliariello V, Calabria D, Calcagno V, De Luca E, Iaffaioli RV, Netti PA. Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the dimensional, compositional and interactional dependence. Journal of Controlled Release. 2016 Jul 10;233:88-100.
Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. British journal of pharmacology. 2017 Jun;174(11):1325-48.
Panahi Y, Sahebkar A, Amiri M, Davoudi SM, Beiraghdar F, Hoseininejad SL, Kolivand M. Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial. British Journal of Nutrition. 2012 Oct;108(7):1272-9.
Al Mijan M, Lim BO. Diets, functional foods, and nutraceuticals as alternative therapies for inflammatory bowel disease: Present status and future trends. World journal of gastroenterology. 2018 Jul 7;24(25):2673.
Rodríguez-Cruz M, del Rocío Cruz-Guzmán O, Almeida-Becerril T, Solís-Serna AD, Atilano-Miguel S, Sánchez-González JR, Barbosa-Cortés L, Ruíz-Cruz ED, Huicochea JC, Cárdenas-Conejo A, Escobar-Cedillo RE. Potential therapeutic impact of omega-3 long chain-polyunsaturated fatty acids on inflammation markers in Duchenne muscular dystrophy: A double-blind, controlled randomized trial. Clinical Nutrition. 2018 Dec 1;37(6):1840-51.
Bansal P, Gupta SK, Ojha SK, Nandave M, Mittal R, Kumari S, Arya DS. Cardioprotective effect of lycopene in the experimental model of myocardial ischemia-reperfusion injury. Molecular and cellular biochemistry. 2006 Sep;289:1-9.
Ojha S, Goyal S, Sharma C, Arora S, Kumari S, Arya DS. Cardioprotective effect of lycopene against isoproterenol-induced myocardial infarction in rats. Human & experimental toxicology. 2013 May;32(5):492-503.
Song B, Liu K, Gao Y, Zhao L, Fang H, Li Y, Pei L, Xu Y. Lycopene and risk of cardiovascular diseases: A meta‐analysis of observational studies. Molecular nutrition & food research. 2017 Sep;61(9):1601009.
Srutkova D, Schwarzer M, Hudcovic T, Zakostelska Z, Drab V, Spanova A, Rittich B, Kozakova H, Schabussova I. Bifidobacterium longum CCM 7952 promotes epithelial barrier function and prevents acute DSS-induced colitis in strictly strain-specific manner. PloS one. 2015 Jul 28;10(7):e0134050..
Sichetti M, De Marco S, Pagiotti R, Traina G, Pietrella D. Anti-inflammatory effect of multistrain probiotic formulation (L. rhamnosus, B. lactis, and B. longum). Nutrition. 2018 Sep 1;53:95-102.
| Volume | 01 |
| Issue | 01 |
| Received | November 23, 2023 |
| Accepted | December 4, 2023 |
| Published | December 27, 2023 |